![]() ![]() Using ‘omics’ to define pathogenesis and biomarkers of Parkinson’s disease. Caudle WM, Bammler TK, Lin Y, Pan S, and Zhang J (2010).Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion. Rostomily RC, Born DE, Beyer RP, Jin J, Alvord EC Jr, Mikheev, AM, Matthews RT, Pan C, Khorasani L, Sonnen JA, Montine TJ, Shi M, and Zhang J (2010).Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by alpha-synuclein. Liu J, Shi M, Hong Z, Zhang J, Bradner J, Quinn T, Beyer RP, Mcgeer PL, Chen S, and Zhang J(2010).Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson’s disease. Shi M, Zabetian CP, Hancock AM, Ginghina C, Hong Z, Yearout D, Chung KA, Quinn JF, Peskind ER, Galasko D, Jankovic J, Leverenz JB, and Zhang J (2010).Mata, I., Zhang, j and Zabeitian C, A SNCA Variant Associated with Parkinson’s Disease and Plasma α-Synuclein Level.Reduction in CSF amyloid b42 without a corresponding increase in tau species is commonly found in patients with Parkinson’s disease and cognitive impairment or dementia. ġ) understand the molecular mechanisms of Parkinson’s disease developmentĢ) understand the molecular mechanisms of Parkinson’s disease progressionģ) explore unique biomarkers for diagnosing Parkinson’s disease and monitoring its progression Finally, the natural course of PD varies substantially, with most patients developing first mild cognitive impairment (MCI) and then dementia as the disease progresses. In addition, there are quite a few other movement disorders that mimic PD clinically including response to levodopa and DA agonists, making an accurate diagnosis of PD difficult sometimes even in the best hands. Despite decades of extensive research, there is currently still no cure for the disease, largely because its pathogenesis has not been fully understood yet. Pathological hallmarks of PD are loss of dopaminergic neurons in the substantia nigra (SN) with resultant depletion of DA and the presence of Lewy bodies in the remaining neurons (indicated by an arrow in the photo micrograph). Parkinson’s disease (PD), the most common serious movement disorder afflicting millions of Americans, is diagnosed when patients present with cardinal parkinsonian signs (bradykinesia, rigidity, tremor, and postural instability as depicted in the diagram on the left) and show a favorable responsiveness to levodopa or dopamine (DA) agonists. ![]()
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